
Decoding Evolutionary Strategies to Control Emerging Pathogens
My team employs an integrative systems biology framework to study two central, interconnected questions critical to public health: (1) how pathogens evolve to evade host defenses and escape our interventions, and (2) how we can leverage this knowledge to develop intervention strategies, ultimately translating this knowledge into first-in-class therapeutics. To this end, my team integrates computational biology and wet experiments, which bridges large-scale computational genomics with experimental validation. By capturing a systems-level view of evolutionary trajectories, my team will uncover the complex adaptive strategies driving pathogenesis, thereby enabling us to anticipate and prepare for potential outbreaks in advance.
For more information, please visit https://gyleelab.com.
